Science · 1982 · 678 citations · 10 references
MedicinePharmacologyCell SignalingMolecular PharmacologyProtein-protein InteractionsLigand BindingLigand Binding KineticsLigand-receptor InteractionsReceptor BindingReceptor PharmacologyReceptor-ligand InteractionsLigand-receptor AffinityProtein-ligand Binding SitesReceptor-ligand Binding AffinityScatchard Analysis
Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.
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Protein interactions with small molecules
Irving M. Klotz · Accounts of Chemical Research · 1974 · 143 citations