Oxaliplatin/fluorouracil/leucovorin (FOLFOX4 and modified FOLFOX6) in patients with refractory or advanced colorectal cancer: post-approval Japanese population experience

Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer

Aimery de Gramont, Arié Figer, Michel Seymour et al. · Journal of Clinical Oncology · 2000 · 3.8K citations

Medicine, Oncology, Pharmacotherapy +11

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

J-Y Douillard, David Cunningham, AD Roth et al. · The Lancet · 2000 · 3.3K citations

Medicine, Oncology, Pharmacology +13

FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study

Christophe Tournigand, Thierry André, Emmanuel Achille et al. · Journal of Clinical Oncology · 2003 · 2.9K citations · Full text

Medicine, Oncology, Pharmacology +13

A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients With Previously Untreated Metastatic Colorectal Cancer

Richard M. Goldberg, Daniel J. Sargent, Roscoe F. Morton et al. · Journal of Clinical Oncology · 2003 · 2.3K citations

Medicine, Oncology, Pharmacology +15

Phase III Multicenter Randomized Trial of Oxaliplatin Added to Chronomodulated Fluorouracil–Leucovorin as First-Line Treatment of Metastatic Colorectal Cancer

Sylvie Giacchetti, B Perpoint, Rachid Zidani et al. · Journal of Clinical Oncology · 2000 · 1.4K citations

Medicine, Oncology, Pharmacology +14