QSAR of 2,4-diphenyl-1,3-oxazolines for ovicidal activity against the two-spotted spider mite Tetranychus urticae

Abstract

Ovicidal activity of 2,4-diphenyl-1,3-oxazoline congeners with various substituents on the 4-phenyl ring against two-spotted spider mites Tetranychus urticae was quantitatively analyzed using the classical QSAR (Hansch-Fujita) method. In QSAR analysis, hydrophobicity in terms of log P (P: partition coefficient between 1-octanol and water) was the most significant parameter with its square term. The optimum log P value for 2,4-diphenyl-1,3-oxazoline analogs was evaluated as about 7.1. The introduction of substituents with inductive electron-withdrawing properties was also favorable to activity, but the presence of substituents at the ortho- and meta-positions was not promising.