Concepedia

Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy

Dongfang Wang, Hangjun Ruan, Lily Hu, Kathleen R. Lamborn, Eileen L Kong, Alnawaz Rehemtulla, Dennis F. Deen

Cancer Gene Therapy · 2005 · 20 citations · 34 references

DOI

Concepts

References

34

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

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Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

Peter Vaupel, F. Kallinowski, Paul Okunieff · PubMed · 1989 · 3.4K citations

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Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

, , +14

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

GL Semenza, Pinchas Roth, Hui‐Yuan Fang et al. · Journal of Biological Chemistry · 1994 · 1.9K citations · Full text

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