Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both <i>Lrp5</i> and <i>Lrp6</i>

Abstract

Lrp6 and Lrp5 genetically interact in limb development in mice. Furthermore, heterozygosity for an inactivating mutation in Lrp6 further reduces BMD in both male and female mice lacking Lrp5.