Concepedia

Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors

Gerard F. Graminski, C. Lance Carlson, Josh R. Ziemer, Feng Cai, Nico Vermeulen, Scott M. Vanderwerf, Mark R. Burns

Bioorganic & Medicinal Chemistry Letters · 2002 · 15 citations · 25 references

DOI

Concepts

References

25

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

Anthony E. Pegg · PubMed · 1988 · 1.5K citations

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Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

Brian W. Metcalf, Philippe Bey, Charles Danzin et al. · Journal of the American Chemical Society · 1978 · 1K citations

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Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase

Yuan‐Ping Pang, Polly A. Quiram, Tanya M. Jelacic et al. · Journal of Biological Chemistry · 1996 · 346 citations · Full text

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Echinomycin: a bifunctional intercalating antibiotic

Michael J. Waring, L. P. G. Wakelin · Nature · 1974 · 284 citations

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Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites.

R. Poulin, Li‐Fan Lu, Bradley L. Ackermann et al. · Journal of Biological Chemistry · 1992 · 217 citations · Full text

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