Nature Structural & Molecular Biology · 2010 · 150 citations · 54 references
Life SciencesCell BiologyMolecular BiologyApoptosisDna RepairMolecular OncologyCancer Cell SignalingDna Damage-induced ApoptosisP53-mediated ApoptosisTumor Suppressor P53
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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations
Medicine, Oncology, Pharmacology +15
Mdm2 promotes the rapid degradation of p53
Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Jiřina Bártková, Zuzana Hořejšı́, Karen Koed et al. · Nature · 2005 · 2.7K citations
Medicine, Cancer Biology, Oncology +16
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey et al. · Science · 1994 · 2.5K citations
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
Sheau-Yann Shieh, Masako Ikeda, Yoichi Taya et al. · Cell · 1997 · 2.1K citations · Full text