Concepedia

AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells

Lyudmyla G. Glushakova, Matthew J. Lisankie, Evgeniy Eruslanov, C. Ojano-Dirain, Irene Zolotukhin, Chen Liu, Arun Srivastava, Peter W. Stacpoole

Molecular Genetics and Metabolism · 2009 · 51 citations · 26 references

DOI

Concepts

References

26

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Pierre Sonveaux, Frédérique Végran, Thies Schroeder et al. · Journal of Clinical Investigation · 2008 · 1.6K citations · Full text

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A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Sébastien Bonnet, Stephen L. Archer, Joan Allalunis‐Turner et al. · Cancer Cell · 2007 · 1.5K citations · Full text

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Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

Carmela Zincarelli, Stephen Soltys, Giuseppe Rengo et al. · Molecular Therapy · 2008 · 1.4K citations · Full text

THE METABOLISM OF TUMORS

OTTO WARBURN, F. Dickens · The American Journal of the Medical Sciences · 1931 · 813 citations

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Rapid Uncoating of Vector Genomes Is the Key toEfficient Liver Transduction with Pseudotyped Adeno-Associated VirusVectors

Clare E. Thomas, Theresa A. Storm, Zan Huang et al. · Journal of Virology · 2004 · 347 citations · Full text