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TRANSFER OF SENSITISED LYT 2<sup>+</sup> CELLS TRIGGERS ACUTE REJECTION OF PANCREATIC ISLET ALLOGRAFTS
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1983
Year
Cellular RequirementsComposite AllograftImmunologyTransplantation MedicineTissue TransplantationPancreas TransplantationImmunotherapyGraft SurvivalCell TransplantationCell SignalingTransplantationXenotransplantationPancreatic Islet BiologyAutoimmunityCultured Islet AllograftsTransplant ImmunologyCell BiologyTransplant RejectionIslet TransplantationSignal TransductionAcute Graft RejectionMedicineGraft Rejection
The cellular requirements for rejection of cultured islet allografts, a tissue expressing only class I alloantigens, have been studied. The results obtained show that sensitised Thy 1+, Lyt 2+ lymphocytes and not Lyt 2- lymphocytes trigger acute graft rejection.