American Journal on Intellectual and Developmental Disabilities · 2009 · 49 citations · 35 references
Life SciencesImmunologyPediatricsDevelopmental ImmunologyImmunopathologyPediatric ImmunologyImmune MaturationLymphocyte DevelopmentT Cell ActivationT Cell BiologyT Cell DevelopmentT Cell DifferentiationImmune Cell ActivationInterferon Gamma ProductionInterferon Gamma ResponseInterferon-gamma ResponsesLymphocyte PhysiologyT Cell ImmunologyT-cell Immune ResponsesT-cell Immunophenotypes
Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.
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