Concepedia

Lack of Pharmacokinetic Interaction for ISIS 113715, a 2???-0-Methoxyethyl Modified Antisense Oligonucleotide Targeting Protein Tyrosine Phosphatase 1B Messenger RNA, with Oral Antidiabetic Compounds Metformin, Glipizide or Rosiglitazone

Richard S. Geary, JoAnn D. Bradley, Tanya Watanabe, Younggil Kwon, Mark K. Wedel, Jan Jaap van Lier, Andr A vanVliet

Clinical Pharmacokinetics · 2006 · 49 citations · 24 references

DOI

Concepts

References

24

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

John V. Frangioni, Pamela H. Beahm, Victor Shifrin et al. · Cell · 1992 · 597 citations

, , +15

Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling

Kathleen A. Kenner, Ezenta Anyanwu, Jerrold M. Olefsky et al. · Journal of Biological Chemistry · 1996 · 433 citations · Full text

, , +16

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Bradley A. Zinker, Cristina M. Rondinone, James M. Trevillyan et al. · Proceedings of the National Academy of Sciences · 2002 · 416 citations

, , +17

Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.

David A. Brown, Shin Hyeok Kang, S. M. Gryaznov et al. · Journal of Biological Chemistry · 1994 · 341 citations · Full text

, , +13

Pharmacokinetic Properties of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats

Richard S. Geary, Tanya Watanabe, L Truong et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 283 citations

, , +15