Concepedia

Analysis of the hypoxia-activated dinitrobenzamide mustard phosphate pre-prodrug PR-104 and its alcohol metabolite PR-104A in plasma and tissues by liquid chromatography–mass spectrometry

Kashyap Patel, David Lewiston, Yongchuan Gu, Kevin O. Hicks, William R. Wilson

Journal of Chromatography B · 2007 · 29 citations · 11 references

DOI

Concepts

References

11

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

Jeremy Brown, Amato J. Giaccia · PubMed · 1998 · 1.5K citations

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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

David M. Brizel, Gregory S. Sibley, Leonard R. Prosnitz et al. · International Journal of Radiation Oncology*Biology*Physics · 1997 · 1.1K citations

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Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

Marianne Nordsmark, Marie Overgaard, Jens Overgaard · Radiotherapy and Oncology · 1996 · 924 citations

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Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

Robert A. Gatenby, Howard Kessler, Jay S. Rosenblum et al. · International Journal of Radiation Oncology*Biology*Physics · 1988 · 805 citations

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Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds et al. · Clinical Cancer Research · 2007 · 247 citations · Full text

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