Life SciencesNutritionNutritional SciencesClinical NutritionClinical PharmacologyHuman NutritionOxidative StressReactive Oxygen SpeciesVitamin PhysiologyAntioxidant VitaminsAssayAtrophic GastritisOxidative Stress InjuryReactive Oxygen Species GenerationReactive Oxygen Species InjuryVitamin C StatusVitamin C Supplementation
BACKGROUND: Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma. AIM OF THE STUDY: Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis. METHODS: A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C. RESULTS: The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01. CONCLUSION: Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis.
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A simple test to monitor oxidative stress.
Cesarone Mr, G Belcaro, M Carratelli et al. · PubMed · 1999 · 440 citations
Oxidative DNA damage accumulation in gastric carcinogenesis
Fabio Farinati, Romilda Cardin, Paolo Degan et al. · Gut · 1998 · 265 citations · Full text