A novel and high-yielding asymmetric synthesis of oseltamivir phosphate (Tamiflu) starting from (−)-shikimic acid

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of the American Chemical Society · 1997 · 1.1K citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

Jesse D. Bloom, Lizhi Ian Gong, David Baltimore · Science · 2010 · 698 citations · Full text

Life Sciences, Evolutionary Biology, Microbiology +17

High‐Yielding Synthesis of the Anti‐Influenza Neuramidase Inhibitor (−)‐Oseltamivir by Three “One‐Pot” Operations

Hayato Ishikawa, Yujiro Hayashi · Angewandte Chemie International Edition · 2009 · 377 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of <i>meso</i>-Aziridines with TMSN₃

Yuhei Fukuta, Tsuyoshi Mita, Nobuhisa Fukuda et al. · Journal of the American Chemical Society · 2006 · 292 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of Medicinal Chemistry · 1998 · 290 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15