An approach to acyclo-3-deazapyrimidine S-nucleosides via 3,5-dicyano-2(1H)-pyridinethiones

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

Hiroaki Mitsuya, Kent J. Weinhold, P A Furman et al. · Proceedings of the National Academy of Sciences · 1985 · 1.9K citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

Douglas D. Richman, Margaret A. Fischl, Michael H. Grieco et al. · New England Journal of Medicine · 1987 · 1.2K citations

Medicine, Hematology, Pharmacology +15

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

Hiroaki Mitsuya, S Broder · Proceedings of the National Academy of Sciences · 1986 · 1K citations · Full text

Life Sciences, Immunology, Infectious Diseases +16

In Vivo Activity Against HIV and Favorable Toxicity Profile of 2′,3′-Dideoxyinosine

Robert Yarchoan, Hiroaki Mitsuya, Rose V. Thomas et al. · Science · 1989 · 425 citations

Medicine, Infectious Diseases, Pharmacology +17

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

Tadashi Miyasaka, Hiromichi Tanaka, Masanori Baba et al. · Journal of Medicinal Chemistry · 1989 · 382 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12