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Synthesis of the C19-C34 Segment of Amphidinolide C
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2007
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Bioorganic ChemistryEngineeringLewis AcidC19-c34 SegmentDiversity-oriented SynthesisNatural SciencesMolecular BiologyOrganic ChemistryChemical BiologySynthetic ChemistryBiomolecular EngineeringAmphidinolide C
The synthesis of the C19-C34 segment of amphidinolide C is described. The key steps include the Mioskowski's Lewis acid catalyzed epoxide opening with the alcohol, ring-closing metathesis, Wittig reaction, and Nozaki-Hiyama-Kishi coupling reaction.