Enzymes Involved in Fructose Metabolism in Liver and the Glyceraldehyde Metabolic Crossroads

Abstract

Fructokinase, the B isoenzyme of fructosediphosphate aldolase and triokinase, the three enzymes of the Hers' pathway for fructose metabolism, are constitutive in adult rats. A quantitative model of the metabolic crossroads of d ‐glyceraldehyde has been developed. This model permits a prediction of the relative contributions of the phosphorylative, oxidative and reductive pathways in different conditions. The main pathway for d ‐glyceraldehyde metabolism in liver is phosphorylation by triokinase.