Mathematical modelling for the assessment of the effect of drug application delays in metronomic chemotherapy of cancer due to physiological constraints

Modern Control Engineering

K. Ogata, J. W. Brewer · Journal of Dynamic Systems Measurement and Control · 1971 · 6.3K citations · Full text

Engineering, Electrical Engineering, Mechanical Engineering +17

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

Giannoula Klement, Sylvain Baruchel, Janusz Rak et al. · Journal of Clinical Investigation · 2000 · 1.2K citations · Full text

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<i>Understanding Nonlinear Dynamics</i>

Daniel T. Kaplan, Leon Glass, Stanley A. Berger · Physics Today · 1996 · 680 citations

Natural Sciences, Physics, Dynamical Systems +11

Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water.

Shan Man, Guido Bocci, Giulio Francia et al. · PubMed · 2002 · 317 citations

Medicine, Oncology, Pharmacology +8

Greater risks of chemotherapy toxicity in elderly patients with cancer.

Lazzaro Repetto · PubMed · 2004 · 205 citations

Medicine, Oncology, Pharmacokinetics +17