The Effect of Antibiotic and Probiotic Combination Therapy on Secondary Pancreatic Infections and Oxidative Stress Parameters in Experimental Acute Necrotizing Pancreatitis

Abstract

Although histopathologic scores in treatment groups were found to be lower than in group VII, the difference was statistically significant only in group V (p < 0.001). In evaluation of oxidative stress, we found that MDA levels decreased and SOD levels increased in treatment groups in comparison with levels in group VII. Probiotic treatment alone reduced bacterial translocation. Probiotic-antibiotic combination therapy was shown to improve histopathologic scores and oxidative parameters.