The effect of age on circulating 6-keto-prostaglandin F1a in humans

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

Salvador Moncada, John R. Vane · New England Journal of Medicine · 1979 · 1.2K citations

Life Sciences, Biochemistry, Pharmacology +17

The chemical structure of prostaglandin X (prostacyclin)

Roy A. Johnson, Douglas R. Morton, John H. Kinner et al. · Prostaglandins · 1976 · 730 citations

Natural Sciences, Chemistry, Pharmacology +10

ARTERIAL THROMBOSIS, INTRAUTERINE DEATH AND "LUPUS" ANTICOAGULANT: DETECTION OF IMMUNOGLOBULIN INTERFERING WITH PROSTACYCLIN FORMATION

L Carreras, S.J. Machin, R DEMAN et al. · The Lancet · 1981 · 554 citations

Medicine, Obstetrics, Pathology +16

Prostacyclin production by cultured smooth muscle cells from atherosclerotic rabbit aorta

J Larrue, Michel Rigaud, Danièle Daret et al. · Nature · 1980 · 96 citations

Life Sciences, Cardiology, Cell Biology +12