Phenolics, inflammation and nutrigenomics

Abstract Nutrigenomics is the study of the effects of bioactive compounds from food on gene expression. In the last several years, an increasing body of scientific evidence has demonstrated that individual compounds, as well as complex mixtures of chemicals, derived from food alter the expression of genes in the human body. By turning on or off genes, bioactives in food alter the concentration of specific proteins directly or indirectly associated with human diseases. Several human diseases result in multiple inflammatory responses which are associated with many diseases including arthritis, cancer, cardiovascular disease, dermatitis, asthma, obesity, and others. Detailed mechanisms of action as to how food derived components play an active role in prevention of inflammation have been elucidated. Such biologically active compounds include theaflavins and catechins from tea, curcumin from turmeric, resveratrol from grapes, and lactones from chicory. While chronic diseases are very complex, an opportunity exists to regulate genes involved in inflammation by enriching our diet with the specific foods inherently rich in such compounds, enriched foods containing standardized extracts of well studied sources, or dietary supplements. Copyright © 2006 Society of Chemical Industry