BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene <i>BRCA1</i>

Yoshio Miki, Jeffrey Swensen, Donna Shattuck-Eidens et al. · Science · 1994 · 6.1K citations

Breast Oncology, Engineering, Genetics +16

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

Kai Rothkamm, Inès Krüger, Larry H. Thompson et al. · Molecular and Cellular Biology · 2003 · 1.2K citations · Full text

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Shyam K. Sharan, Masami Morimatsu, Urs Albrecht et al. · Nature · 1997 · 1.1K citations

Knockout Mouse, Genome Instability, Developmental Biology +8

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

Mary Ellen Moynahan, Andrew J. Pierce, Maria Jasin · Molecular Cell · 2001 · 998 citations · Full text

Chromatin, Genome Instability, Homology-directed Repair +5

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Arkady Celeste, Óscar Fernández-Capetillo, Michael J. Kruhlak et al. · Nature Cell Biology · 2003 · 983 citations

Histone Modifications, Chromatin, Genome Instability +15