Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B

A C. elegans mutant that lives twice as long as wild type

Cynthia Kenyon, Jean Chang, Erin Gensch et al. · Nature · 1993 · 3.4K citations

Life Sciences, Biology, Genetics +6

<i>daf-16</i> : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of <i>Caenorhabditis elegans</i>

Kui Lin, Jennie B. Dorman, Aylin R. Rodan et al. · Science · 1997 · 1.5K citations

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FOXO3A genotype is strongly associated with human longevity

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

Dae‐Sung Hwangbo, Boris Gersham, Meng‐Ping Tu et al. · Nature · 2004 · 975 citations

Life Sciences, Biology, Genetics +14

Association of <i>FOXO3A</i> variation with human longevity confirmed in German centenarians

Friederike Flachsbart, Amke Caliebe, Rabea Kleindorp et al. · Proceedings of the National Academy of Sciences · 2009 · 571 citations

Education, Genetics, Molecular Genetics +13