Association of <i>FOXO3A</i> variation with human longevity confirmed in German centenarians

Friederike Flachsbart, Amke Caliebe, Rabea Kleindorp, +5

Proceedings of the National Academy of Sciences

A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals

Almut Nebel, Rabea Kleindorp, Amke Caliebe, +13

Mechanisms of Ageing and Development

Genome-wide Association StudyAllelic VariantAgingGenotype-phenotype AssociationLongevity +8

Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

Mette Soerensen, Serena Dato, Qihua Tan, +16

AGE

Lifespan ExtensionLongitudinal StudiesAgingLongevityGenetics +7

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies

Mette Soerensen, Serena Dato, Qihua Tan, +16

Experimental Gerontology

Lifespan ExtensionMetabolic SyndromeAnti-agingAgingLongevity +10

A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians

Almut Nebel, Friederike Flachsbart, Andreas Till, +7

Mechanisms of Ageing and Development

Lifespan ExtensionAgingLongevityGeneticsPathology +6

Candidate gene study of <i>FOXO1</i>, <i>FOXO4</i>, and <i>FOXO6</i> reveals no association with human longevity in Germans

Rabea Kleindorp, Friederike Flachsbart, Annibale Alessandro Puca, +3

Aging Cell

AgingGeneticsGenomicsBiogerontologyFoxo Genes +16

Investigation of genetic susceptibility factors for human longevity – A targeted nonsynonymous SNP study

Friederike Flachsbart, André Franke, Rabea Kleindorp, +4

Mutation research. Fundamental and molecular mechanisms of mutagenesis

Lifespan ExtensionAgingLongevityGeneticsNonsynonymous Snp Study +6

Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B

Friederike Flachsbart, Michael Mӧller, Carolin Däumer, +6

European Journal of Human Genetics

BiologySpecial AttentionFunctional GenomicsComparative GenomicsGenetics +9

Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans

Markus Ralser, Almut Nebel, Rabea Kleindorp, +5

BMC Genetics

Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals

Friederike Flachsbart, Amke Caliebe, Michael Nothnagel, +4

European Journal of Human Genetics

Alzheimer's DiseaseAgingVascular Cognitive DisorderDementiaGenetic Epidemiology +11