Concepedia

Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases

Gisele Nishiguchi, Gordana Atallah, Cornelia Bellamacina, Matthew T. Burger, Yu Ding, Paul Feucht, Pablo D. García, Wooseok Han, Liana M. Klivansky, Mika Lindvall

Bioorganic & Medicinal Chemistry Letters · 2011 · 63 citations · 19 references

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19

Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors

Harald Mikkers, Martijn C. Nawijn, John Allen et al. · Molecular and Cellular Biology · 2004 · 319 citations · Full text

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Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase

Kevin Qian, Lian Wang, Eugene R. Hickey et al. · Journal of Biological Chemistry · 2004 · 288 citations · Full text

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Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

Daisuke Morishita, Ryohei Katayama, Kazuhisa Sekimizu et al. · Cancer Research · 2008 · 286 citations

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The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

Robert Amson, F Sigaux, Serge Przedborski et al. · Proceedings of the National Academy of Sciences · 1989 · 234 citations · Full text

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Structure and Substrate Specificity of the Pim-1 Kinase

Alex N. Bullock, J.E. Debreczeni, A. Amos et al. · Journal of Biological Chemistry · 2005 · 199 citations · Full text

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