Successful Treatment of Behcet Disease with Pentoxifylline

Abstract

Brief Reports15 May 1996Successful Treatment of Behcet Disease with PentoxifyllineKozo Yasui, MD, Kouichi Ohta, MD, Masakazu Kobayashi, MD, Toru Aizawa, MD, and Atsushi Komiyama, MDKozo Yasui, MD, Kouichi Ohta, MD, Masakazu Kobayashi, MD, Toru Aizawa, MD, and Atsushi Komiyama, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Behcet disease is a chronic condition that is common in Japan and the countries on the Mediterranean Sea. Its cause is still unknown, but its occurrence is strongly associated with HLA-B51 antigen. Neutrophil motility and superoxide production are characteristically increased in patients with Behcet disease.Pentoxifylline is a membrane fluidizer that modulates receptor-mediated cellular functions [1]. It also modulates neutrophil motility, suppresses production of superoxide anion (O2−), and reduces neutrophil-induced tissue damage [1, 2].We examined the effect of pentoxifylline in controlling Behcet disease. We administered 600 mg of pentoxifylline per day, in two doses, to three male patients and ...References1. Hill HR, Augustine NH, Newton JA, Shigeoka AO, Morris E, Sacchi F. Correction of a developmental defect in neutrophil activation and movement. Am J Pathol. 1987; 128:307-14. Google Scholar2. Buescher ES, Mcllheran SM, Banks SM, Vadhan-Raj S. Alteration of the functional effects of granulocyte-macrophage colony-stimulating factor on polymorphonuclear leukocytes by membrane-fluidizing agents. Infect Immun. 1990; 58:3002-8. Google Scholar3. Nelson RD, Quie PG, Simmons RL. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol. 1975; 115:1650-6. Google Scholar4. 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Effect of microtubule-disrupting agents on superoxide production in human polymorphonuclear leukocytes. Biochim Biophys Acta. 1982; 719:589-98. Google Scholar9. Aktulga E, Altac M, Muftuoglu A, Ozyazgan Y, Pazarli H, Tuzun Y, et al. A double blind study of colchicine in Behcet's disease. Haematologica. 1980; 65:399-402. Google Scholar10. Yazici H, Barnes CG. Practical treatment recommendations for pharmacotherapy of Behcet's syndrome. Drugs. 1991; 42:796-804. Google Scholar11. Lingenfelser T, Duerk H, Stevens A, Grossmann T, Knorr M, Saal JG. Generalized myositis in Behcet disease: treatment with cyclosporine. Ann Intern Med. 1992; 116:651-3. 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