Concepedia

Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

G. Darby, H. J. Field, Stephen A. Salisbury

Nature · 1981 · 203 citations · 22 references

DOI

Concepts

References

22

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

Gertrude B. Elion, Phillip A. Furman, James A. Fyfe et al. · Proceedings of the National Academy of Sciences · 1977 · 1.6K citations · Full text

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9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

H. J. Schaeffer, Lilia M. Beauchamp, P de Miranda et al. · Nature · 1978 · 1.1K citations

, , +8

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

James A. Fyfe, Paul M. Keller, P A Furman et al. · Journal of Biological Chemistry · 1978 · 562 citations · Full text

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Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease

T. J. Hill, Hugh J. Field, W. A. Blyth · Journal of General Virology · 1975 · 338 citations

, , +10

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

Hugh J. Field, P. Wildy · Journal of Hygiene · 1978 · 336 citations · Full text

, , +14