Synthesis of Amphiphilic Piperidinium Derivatives. Cationic Lipids 41

Abstract

A series of novel amphiphilic piperidinium salts for use in cationic liposome mediated gene transfection was prepared. The synthesis involves the introduction of the lipophilic part of the cationic lipid through formation of biodegradable ester bonds, with subsequent alkylation of the heterocyclic nitrogen atoms to complete the lipid polar head group.