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Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-<i>d</i>]Pyrimidine Ribonucleosides
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Citations
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2009
Year
Medicinal ChemistryPharmaceutical ChemistryHepatitis C VirusNatural SciencesMedicineAntiviral Drug DevelopmentMeaningful Anti-hcv ActivityAntiviral TherapyOrganic ChemistryChemistryAntiviral Evaluation2′-C-methyl AnaloguesPharmacologyAntiviral CompoundNew Nucleoside AnaloguesAntiviral DrugBiomolecular EngineeringDrug Discovery
A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.
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