Toll like receptor 4 (TLR4) mediates the stimulating activities of chitosan oligosaccharide on macrophages

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Life Sciences, Genetics, Immunology +15

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (<i>Tlr4</i>)

Salman T. Qureshi, Line Larivière, Gary Leveque et al. · The Journal of Experimental Medicine · 1999 · 1.5K citations · Full text

Life Sciences, Genetics, Immunology +17

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

Hye Sun Park, Hye Young Jung, Eun Young Park et al. · The Journal of Immunology · 2004 · 634 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose

Ko Suzuki, Takeshi Mikami, Yoshio Okawa et al. · Carbohydrate Research · 1986 · 448 citations

Medicine, Biochemistry, Oncology +7

Immunological activity of chitin and its derivatives

Keiko Nishimura, S. Nishimura, Nobuyuki Nishi et al. · Vaccine · 1984 · 395 citations

Life Sciences, Biochemistry, Immunology +6