Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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Medicine, Biochemistry, Pharmacology +15

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

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Life Sciences, Biochemistry, Molecular Biology +9

Maintenance of differentiated rat hepatocytes in primary culture.

Harriet C. Isom, T. E. Secott, Ingo Georgoff et al. · Proceedings of the National Academy of Sciences · 1985 · 358 citations · Full text

Medicine, Biochemistry, Cell Biology +15

Valproic Acid Induces CYP3A4 and MDR1 Gene Expression by Activation of Constitutive Androstane Receptor and Pregnane X Receptor Pathways

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Life Sciences, Molecular Biology, Pharmacology +17

Identification of multiple regulatory elements on the human cytochrome P450IA1 gene

Ronald N. Hines, J. Michael Mathis, Cynthia S. Jacob · Carcinogenesis · 1988 · 118 citations

Life Sciences, Genetics, Molecular Biology +16