CPT loaded nanoparticles based on beta-cyclodextrin-grafted poly(ethylene glycol)/poly (l-glutamic acid) diblock copolymer and their inclusion complexes with CPT

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Block copolymer micelles for drug delivery: design, characterization and biological significance

Kazunori Kataoka, Atsushi Harada, Yukio Nagasaki · Advanced Drug Delivery Reviews · 2001 · 3.5K citations

Pharmacy, Pharmaceutics, Pharmacokinetics +16

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

Ron H.J. Mathijssen, R J van Alphen, Jaco J. Verweij et al. · PubMed · 2001 · 752 citations · Full text

Medicine, Oncology, Pharmacology +17

Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

Youqing Shen, Erlei Jin, Bo Zhang et al. · Journal of the American Chemical Society · 2010 · 566 citations

Pharmacy, Pharmaceutics, Pharmacology +17

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Julianne Fassberg, Valentino J. Stella · Journal of Pharmaceutical Sciences · 1992 · 464 citations

Life Sciences, Biochemistry, Chemistry +12