Targeting RAS-MAPK-ERK and PI3K-AKT-mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.1K citations

Pharmacological Study, Pharmacoepidemiology, Quantitative Analysis +10

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

Engineering, Network Science, P53 Network +5

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

Genetic Analysis, Mobility Shift Analysis, Genetic Testing +15

A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995

Scott A. Hundahl, Irvin D. Fleming, Amy M. Fremgen et al. · Cancer · 1998 · 1.8K citations · Full text

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

Christian Rommel, Brian Clarke, Sven Zimmermann et al. · Science · 1999 · 766 citations

Muscle Function, Erk Kinase, Cytoskeleton +17