Concepedia

Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors

Umar Faruk Mansoor, Angie R. Angeles, Chaoyang Dai, Liping Yang, Andrea Basso, Kimberly Gray, Huadong Tang, Ming Liu, Lianzhu Liang, Omaira Allbritton,

Bioorganic & Medicinal Chemistry · 2015 · 15 citations · 12 references

DOIFull text

Open access

Concepts

References

12

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

Thomas U. Mayer, Tarun M. Kapoor, Stephen J. Haggarty et al. · Science · 1999 · 1.7K citations

, , +17

Evidence that Monastrol Is an Allosteric Inhibitor of the Mitotic Kinesin Eg5

Zoltan Maliga, Tarun M. Kapoor, Timothy J. Mitchison · Chemistry & Biology · 2002 · 290 citations · Full text

, , +14

Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Youwei Yan, Vinod Sardana, Bei Xu et al. · Journal of Molecular Biology · 2003 · 204 citations

, , +14

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2<i>S</i>)-4-(2,5-Difluorophenyl)-<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-<i>N</i>-methyl-2-phenyl-2,5-dihydro-1<i>H</i>-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox, Paul J. Coleman, Michael J. Breslin et al. · Journal of Medicinal Chemistry · 2008 · 156 citations · Full text

, , +13

280. Aliphatic nitro-compounds. Part I. Preparation of nitro-olefins by dehydration of 2-nitro-alcohols

G. D. Buckley, Charles W. J. Scaife · Journal of the Chemical Society (Resumed) · 1947 · 98 citations

, , +2