Concepedia

Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression

Young‐Sun Kim, Hyeon‐Ok Jin, Sung‐Keum Seo, Sang Hyeok Woo, Taeboo Choe, Sungkwan An, Seok‐Il Hong, Su‐Jae Lee, Kee-Ho Lee, In‐Chul Park

Biochemical Pharmacology · 2011 · 47 citations · 19 references

DOI

Concepts

References

19

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

, , +14

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Eric J. Brown, Mark W. Albers, Tae Bum Shin et al. · Nature · 1994 · 2.1K citations

, , +11

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

James Brugarolas, Kui Lei, Rebecca L. Hurley et al. · Genes & Development · 2004 · 1.4K citations · Full text

, , +17

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Patrick E. Burnett, Roxanne K. Barrow, Noam A. Cohen et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations

, , +14

CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

Hirohito Yamaguchi, Hong‐Gang Wang · Journal of Biological Chemistry · 2004 · 834 citations · Full text

, , +17