Expression of eukaryotic translation initiation factors 4E and 2? is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

Abstract

Increased expression of either one or both translation initiation factors may facilitate accelerated growth and division of neoplastic cells in BA carcinoma of the lung. However, the current findings suggest a possibility that increased cell growth and proliferation in SC carcinoma may be achieved through a mechanism independent of increases in eIF-4E and eIF-2alpha expression.