The Anti-HIV Potency of Cyclotriazadisulfonamide Analogs Is Directly Correlated with Their Ability to Down-Modulate the CD4 Receptor

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

Angus Dalgleish, Peter C. L. Beverley, Paul R. Clapham et al. · Nature · 1984 · 3.5K citations

Life Sciences, Immunology, Molecular Biology +14

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

David Klatzmann, Éric Champagne, S. Chamaret et al. · Nature · 1984 · 2.4K citations

Life Sciences, Immunology, Molecular Biology +14

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

Paul J. Maddon, Angus Dalgleish, J. Steven McDougal et al. · Cell · 1986 · 2K citations

Life Sciences, Immunology, Molecular Biology +10

Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein

Trevor L. Hoffman, Celia C. LaBranche, Wentao Zhang et al. · Proceedings of the National Academy of Sciences · 1999 · 265 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +9

CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1

Susan L. Kozak, Emily J. Platt, Navid Madani et al. · Journal of Virology · 1997 · 234 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +12