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A Transcription Map of the Major Histocompatibility Complex (MHC) Class I Region
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1996
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HistocompatibilityGeneticsHla ImmunogeneticsGenomic MechanismMajor Histocompatibility ComplexGene CharacterizationMolecular GeneticsAntigen ProcessingGenomicsImmune SystemEpigeneticsImmunogeneticsZinc Finger GenesCdna Hybridization SelectionGene ExpressionFunctional GenomicsCell BiologyChromatinEpigenomicsHla TypingSystems BiologyMedicineTranscription Map
We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.