Concepedia

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

Pooja Jha, Thierry Claudel, Anna Baghdasaryan, Michaela Mueller, Emina Halilbasic, Suman K. Das, Achim Lass, Robert Zimmermann, Rudolf Zechner, Gerald Höefler,

Hepatology · 2013 · 97 citations · 26 references

DOIFull text

Open access

Abstract

These findings unravel a novel protective role of ATGL against hepatic inflammation which could have important implications for metabolic and inflammatory liver diseases.

References

26

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Kerry L. Donnelly, Coleman I. Smith, Sarah Jane Schwarzenberg et al. · Journal of Clinical Investigation · 2005 · 3.4K citations · Full text

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Jorge Henao‐Mejia, Eran Elinav, Chengcheng Jin et al. · Nature · 2012 · 2.4K citations

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Michael K. Badman, Pavlos Pissios, Adam R. Kennedy et al. · Cell Metabolism · 2007 · 1.5K citations · Full text

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Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase

Guenter Haemmerle, Achim Lass, Robert Zimmermann et al. · Science · 2006 · 1.4K citations · Full text

, , +12

The PPARα–leukotriene B4 pathway to inflammation control

Pallavi R. Devchand, H. J. Keller, Jeffrey M. Peters et al. · Nature · 1996 · 1.3K citations

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