Diurnal Patterns of Plasma Triglycerides and Free Fatty Acids in Normal Subjects and in Patients with Endogenous (Type IV) Hyperlipoproteinemia

Abstract

Controlled dietary studies with formula diets in normal subjects and in patients with type IV hyperglyceridemia were performed, comparing high fat (65% of total calories) with high carbohydrate (80% of total calories) diets. In spite of ‘carbohydrate-accentuation’ on the latter diet, as judged from fasting triglyceride values, all-day triglyceride levels were higher with 65% fat formula, particularly in the patient group. Since all-day free fatty acid levels showed similar behaviour, it is suggested that control of endogenous hyperlipidemia may require a properly balanced diet rather than extreme carbohydrate restriction and fat supplementation.