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Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors

Tzung-Sheng Lin, Ya‐Wen Liw, Jen‐Shin Song, Tsung-Chih Hsieh, Hsien‐Wei Yeh, Lih‐Ching Hsu, Chun‐Jung Lin, Szu‐Huei Wu, Pi‐Hui Liang

Bioorganic & Medicinal Chemistry · 2013 · 18 citations · 30 references

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30

Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Wei Meng, Bruce A. Ellsworth, Alexandra A. Nirschl et al. · Journal of Medicinal Chemistry · 2008 · 628 citations · Full text

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The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.

Y. Kanai, W S Lee, Dennis Brown et al. · Journal of Clinical Investigation · 1994 · 624 citations · Full text

, , +15

Empagliflozin, a novel selective sodium glucose cotransporter‐2 (SGLT‐2) inhibitor: characterisation and comparison with other SGLT‐2 inhibitors

Rolf Grempler, Leo Thomas, Matthias Eckhardt et al. · Diabetes Obesity and Metabolism · 2011 · 603 citations

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Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter

E. Turk, B. Zabel, Stefan Mundlos et al. · Nature · 1991 · 385 citations

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Discovery of Canagliflozin, a Novel <i>C</i>-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

Sumihiro Nomura, Shigeki Sakamaki, Mitsuya Hongu et al. · Journal of Medicinal Chemistry · 2010 · 379 citations · Full text

, , +17