Therapeutic potential of ghrelin treatment for unloading-induced muscle atrophy in mice

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Masayasu Kojima, Hiroshi Hosoda, Yukari Date et al. · Nature · 1999 · 8.4K citations

Growth Hormone, Biochemistry, Physiology +5

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

Sue C. Bodine, Esther Latres, Susanne Baumhueter et al. · Science · 2001 · 3.4K citations · Full text

A role for ghrelin in the central regulation of feeding

Masamitsu Nakazato, Noboru Murakami, Yukari Date et al. · Nature · 2001 · 3.4K citations

Animal Physiology, Nutrition, Biology +10

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

Marco Sandri, Claudia Sandri, Alex Gilbert et al. · Cell · 2004 · 2.9K citations · Full text

Transcriptional Regulation, Skeletal Muscle, Genetics +6

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez et al. · Nature Cell Biology · 2001 · 2.7K citations

Skeletal Muscle Hypertrophy, Molecular Physiology, Muscle Injury +10