Conjugation of ATIII‐Binding Pentasaccharides to Extend the Half‐Life of Proteins: Long‐Acting Insulin

Abstract

CarboCarriertm: Site-specific conjugation of insulin to a synthetic antithrombin III (ATIII)-binding pentasaccharide (PS) improves the protein's half-life and extends the duration of action. The half-life can be adjusted by changing the PS affinity for ATIII. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2008/z800053_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.