Cell Cycle · 2004 · 238 citations · 0 references
Life SciencesGeneticsOncologyCancer GeneticsCarcinogenesisMolecular OncologyCancer Genomic InstabilityDna Polymerase FunctionDna Repair DefectsDna Repair In CarcinogenesisMalignant NeoplasmsPolymerase Chain ReactionBase Excision Repair DefectsCancer-associated Defects In Nucleotide Excision RepairDna Polymerase BetaMutator AllelesMutator PhenotypesProtein OverexpressionTelomere Fusions
Cells transduce mechanical forces into biochemical signals; traditionally these processes are thought to occur through direct effects on the cell membrane, the cytoskeleton, or specific transmembrane proteins. In multicellular tissues mechanical forces alter intercellular spacing through redistribution of interstitial fluid. Recent morphological and biochemical observations, bolstered by analytical modeling, support a new paradigm for mechanotransduction arising from constitutive growth factor shedding into a dynamically regulated interstitial volume.