Mutator Phenotype is a bacterial phenotype characterized by an elevated mutation rate due to defects in DNA mismatch repair, distinguishing it from wild-type phenotypes by its increased genetic instability and contribution to adaptive evolution.
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Mutator phenotype may be required for multistage carcinogenesis.
Hypermutability and mismatch repair deficiency in RER+ tumor cells
Ramon Parsons, Guo‐Min Li, Matthew J. Longley et al. · Cell · 1993 · 1.1K citations
Life Sciences, Genetics, Oncology +17
High Mutation Frequencies Among <i>Escherichia coli</i> and <i>Salmonella</i> Pathogens
J. Eugene LeClerc, Baoguang Li, W L Payne et al. · Science · 1996 · 846 citations
A Mutator Phenotype in Cancer 1
Lawrence A. Loeb · 2001 · 672 citations
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- RMRoel M. Schaaper
National Institute of Environmental Health Sciences, United States
22 publications · 1.3K citations
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- MPManuel Perucho
Sanford Burnham Prebys Medical Discovery Institute, United States
16 publications · 3.1K citations
15
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- JHJeffrey H Miller
University of California, Los Angeles, United States
15 publications · 2.4K citations
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- TAThomas A. Kunkel
National Institute of Environmental Health Sciences, United States
16 publications · 1.2K citations
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National Institute of Environmental Health Sciences
Durham, United States
34 h-index
136 publications
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University of Washington
Seattle, United States
22 h-index
127 publications
11K citations
Yale University
New Haven, United States
19 h-index
73 publications
4.3K citations
Centre National de la Recherche Scientifique
Paris, France
18 h-index
83 publications
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Harvard University
Cambridge, United States
18 h-index
52 publications
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Rutgers, The State University of New Jersey
New Brunswick, United States
17 h-index
53 publications
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Paris, France
17 h-index
61 publications
4.7K citations
National Institutes of Health
Bethesda, United States
16 h-index
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PNAS · 82 publications · 13.4K citations
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JB · 71 publications · 4.8K citations
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Repository · 64 publications · 7.3K citations
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37 publications · 2.2K citations
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