Chemical and Pharmaceutical Bulletin · 1985 · 82 citations · 1 references
PharmacyBotanyPharmacologyDrug DiscoveryPlant BiochemistryStructure-activity RelationshipsEicosanoid BiosynthesisMedicinal PlantsNatural Product Drug DiscoveryPhenylpropanoid BiosynthesisStructure-activity Relationship AnalysisTerpenoid BiosynthesisArachidonic Acid BiosynthesisArachidonic Acid MetabolitesArachidonic Acid SignalingBioactive Plant CompoundsPhenolic CompoundsPlant-derived Natural ProductsPlatelet Aggregation InhibitionProstaglandin Biosynthesis Inhibitors
From the heartwood of Dalbergia odorifera T. Chen, a Chinese medicinal drug (Japanese name "Koshinko") used for the stagnation of disordered blood, five new phenolic compounds, isomucronustyrene (2) and hydroxyobtustyrene (3) (cinnamylphenol), (±)-isoduartin (6) (isoflavan), odoriflavene (7) (isoflav-3-ene) and (-)-odoricarpan (15) (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, the cinnamylphenols, isoflavans, isoflav-3-ene and a benzoic acid derivative inhibited prostaglandin biosynthesis more than the pterocarpan and isoflavone compounds.
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