Concepedia

Drug–drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4

Sheila J. Sadeghi, Silvia Ferrero, Giovanna Di Nardo, Gianfranco Gilardi

Bioelectrochemistry · 2012 · 51 citations · 22 references

Open access

Concepts

MedicineBiochemistryPharmacologyDrug InteractionsElectroanalytical MethodsMolecular PharmacologyCytochrome P450 EnzymesCytochrome P450 InteractionsDrug-drug InteractionsDrug-metabolizing EnzymesMechanisms Of Drug ActionPharmacokinetic Drug InteractionsCyp450-mediated InteractionsCytochrome P450 3A4 MetabolismCytochrome P450 Drug MetabolismCytochrome P450 Enzyme ActivityCytochrome P450 KineticsCytochrome P450 Ligand BindingCytochrome P450 Reaction Mechanisms

References

22

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

T. Nash · Biochemical Journal · 1953 · 4.4K citations · Full text

Natural Sciences, Biochemistry, Chemistry +7

Cytochrome P450: Structure, mechanism, and biochemistry

W. A. PRYOR · Free Radical Biology and Medicine · 1996 · 1.6K citations

Medicine, Biochemistry, Pharmacology +12

Structural basis for ligand promiscuity in cytochrome P450 3A4

M. Ekroos, Tove Sjögren · Proceedings of the National Academy of Sciences · 2006 · 756 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution

Jason K. Yano, Michael R. Wester, G. Schoch et al. · Journal of Biological Chemistry · 2004 · 699 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models: Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

Ken Korzekwa, N. Krishnamachary, Magang Shou et al. · Biochemistry · 1998 · 519 citations

Medicine, Pharmacokinetics, Pharmacology +17