Facial Palsy As a Side Effect of Vemurafenib Treatment in Patients With Metastatic Melanoma

Abstract

A 63-year-old man (Table Additional metastatic sites included the right femur, right deltoid muscle, right axillary lymph nodes, right atrium, and a large mediastinal mass. There was no previous melanoma history, and a primary melanoma could not be identified at the time of diagnosis. The right foot was amputated for pain control, and palliative radiotherapy was administered to the axillary and femoral metastases. The soft tissue metastasis from the deltoid muscle was surgically removed and molecular testing demonstrated the presence of a BRAF V600E mutation. After two cycles of dacarbazine chemotherapy, there was progressive disease with a new left-sided rib metastasis.