Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Dennis M. Klinman, Ae‐Kyung Yi, Serge L. Beaucage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations · Full text

Innate Immune System, Bacteriology, Immunology +18

IL-4 directs the development of Th2-like helper effectors.

Susan L. Swain, Andrew D. Weinberg, M English et al. · The Journal of Immunology · 1990 · 1.3K citations · Full text

Lymphocyte Development, Immunology, Immune Regulation +17

Interferon-γ: the Major Mediator of Resistance Against <i>Toxoplasma gondii</i>

Yasuhiro Suzuki, Manuel Orellana, Robert D. Schreiber et al. · Science · 1988 · 1.2K citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

Yukio Sato, Mark Roman, Helen Tighe et al. · Science · 1996 · 1.1K citations

Immunogenetics, Autoimmune Disease, Allergy +14

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Graham Le Gros, Shlomo Z. Ben‐Sasson, Robert A. Seder et al. · The Journal of Experimental Medicine · 1990 · 952 citations · Full text

Adaptive Immune System, Immunology, Immune Regulation +16