Bioorganic & Medicinal Chemistry · 2007 · 81 citations · 31 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignLead OptimizationStructure-activity RelationshipsBeta-lactam ResistanceChemical Space ExplorationLigand-based DesignPotency OptimizationStructure-activity Relationship AnalysisStructure-based Pharmacophore ModelingAmpc Beta-lactamasesBeta-lactamase InhibitorsBeta-lactamase Structure-function RelationshipsNovel Beta-lactamase DiscoveryStructure-activity Relationship Guided Designβ-Lactam Antibiotics
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Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
Daniel Weinreich, Nigel F. Delaney, Mark A. DePristo et al. · Science · 2006 · 1.5K citations